Illustration indicating the inhibition of the EGF receptor [green] by targeting the extracellular domain with the therapeutic monoclonal antibody Cetuximab [cyan]. Shown in the foreground is the Fab fragment of Cetaximab antibody in complex with the extracellular domain of an EGF receptor monomer. In the unliganded state, monomeric EGF receptor predominantly maintains a tethered conformation. BInding of EGF ligand (pink) promotes rearrangement of the receptor to an extended conformation. Rendered using Visual Molecular Dynamics (VMD), 3D Studio Max, After Effects, and Adobe Photoshop.